Development of Bioactive Foldamers Using Ribosomally Synthesized Nonstandard Peptide Libraries
نویسندگان
چکیده
منابع مشابه
Natural Ribosomally Synthesized Circular Proteins
Over recent years several examples of natural ribosomally synthesized circular proteins from a diverse range of organisms have been discovered. They are special molecules, whose precursors must be posttranslationally modified to join the N to C termini with a head-to-tail peptide bond. This feature appears to have a range of potential advantages over their linear counterparts, since they are le...
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This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
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Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a growing class of natural products that are found in all domains of life. These compounds possess vast structural diversity and have a wide range of biological activities, promising a fertile ground for exploring novel natural products. One challenging aspect of RiPP research is the difficulty of structure determinat...
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The presence of a nonproteinogenic moiety in a nonstandard peptide often improves the biological properties of the peptide. Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diagnostic applications. Highly diverse non-standard peptide libraries can be generated by chemically or enzymatically modifying standard peptide libraries synth...
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Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide foldamers. This strategy relies on the post-modification of a reactive peptide precursor that can be prepared via standard solid phase peptide syn...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 2021
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.20200326